Liquid chromatography–mass spectrometry (LC-MS) couples separation with m/z-based detection to identify and quantify analytes in complex matrices. Together with our partners around the world, we diligently strive to be a company that meets the challenges faced by society and develop products which contribute to the. Explore Liquid Chromatography Mass Spectrometry (LCMS) in pharmaceutical development – learn structure elucidation, ionisation modes, mass analyser, and expert tips with real-world case studies Liquid Chromatography-Mass Spectrometry (HPLCMS or LCMS) is the integration of the two systems, HPLC and. Van Deemter plots in HPLC as a function of particles size.